Summary
This blend pairs a GHRH analog (usually CJC-1295 without DAC) with the ghrelin-receptor agonist ipamorelin. The two act on different pituitary receptors. Synergy between those two receptor classes is well documented for related compounds, but this exact pairing has not been studied in a published trial.
Components
- GHRH analog CJC-1295 (no DAC) CJC-1295 without DAC, also called Modified GRF (1-29), is sermorelin with four amino acid substitutions that make it more resistant to breakdown. Animal studies
- Selective ghrelin-receptor agonist Ipamorelin Ipamorelin is a five-residue ghrelin-receptor agonist described in 1998 as the first selective growth hormone secretagogue. Human RCTs
How it works
GHRH analogs increase how much GH each somatotroph releases, while ghrelin-receptor agonists increase the number of cells releasing and blunt somatostatin. Combined stimulation of both receptors produces more GH than either alone in classic studies of GHRH plus GHRPs.
Research use cases
Areas where CJC-1295 + Ipamorelin blend has been studied. Inclusion here does not mean it works for that purpose.
- Combines the research areas of its components; see each component profile
What the research found
No combination studies
We found no published peer-reviewed study testing this exact combination in animals or people. Evidence comes only from studies of each component on its own.
Safety and open questions
Combining compounds can change how each behaves, and fixed ratios mean you cannot adjust one without the other. Component purity and identity are harder to verify in a blend, because a single certificate of analysis must confirm several peptides.
Regulatory status
Not approved. A supplier-defined combination; no regulator has evaluated it.
Status was accurate when this page was last reviewed on October 26, 2026. Regulations change; check with the relevant authority before relying on it.
CJC-1295 + Ipamorelin blend: common questions
How do I calculate amounts for a blend?
All components dissolve into the same water, so every draw contains them in the same ratio as the vial. Use the blend calculator, which shows the amount of each component per draw.
Does the blend use CJC-1295 with or without DAC?
It varies by supplier. Most use the no-DAC version, but check the label and certificate of analysis, because the two behave very differently.
Is CJC-1295 + Ipamorelin blend approved for human use?
Not approved. A supplier-defined combination; no regulator has evaluated it.