Independent peptide research reference
What the research actually shows
Plain-language profiles of 85 peptides and related compounds, each rated by the strength of its evidence and linked to the studies behind every claim. Plus reconstitution calculators that do the arithmetic and nothing else.
- G1
- E2
- P3
- P4
- P5
- G6
- K7
- P8
- A9
- D10
- D11
- A12
- G13
- L14
- V15
HydrophobicGly / ProPolarBasic (+)Acidic (−)
Evidence scale
Every compound carries one label
The label reflects the strongest kind of evidence that exists, not how promising a compound sounds. A striking result in mice is still an animal result.
- Approved medicineApproved by the FDA or another major regulator for at least one indication.19 compounds
- Human RCTsRandomized, controlled trials in people, but not approved for the use described.10 compounds
- Early human dataSmall, uncontrolled or single-site human studies, case series or pharmacology studies.14 compounds
- Animal studiesFindings come mainly from rodent or other animal models.39 compounds
- Cell studiesFindings come mainly from cell culture or biochemical assays.3 compounds
Most researched
Start with these profiles
- GLP-1 receptor agonist Semaglutide Semaglutide is a long-acting GLP-1 receptor agonist approved for type 2 diabetes, chronic weight management and cardiovascular risk reduction. Approved medicine
- GIP and GLP-1 receptor agonist Tirzepatide Tirzepatide activates both the GIP and GLP-1 receptors. Approved medicine
- GIP, GLP-1 and glucagon receptor agonist Retatrutide Retatrutide is an investigational triple agonist of the GIP, GLP-1 and glucagon receptors. Human RCTs
- Synthetic pentadecapeptide BPC-157 BPC-157 is a synthetic 15-amino-acid peptide studied mainly for tendon, ligament, muscle and gut healing in rodents. Animal studies
- Thymosin beta-4 peptide TB-500 TB-500 is the trade name for synthetic thymosin beta-4 or its active fragment. Early human data
- Copper-binding tripeptide GHK-Cu GHK-Cu is a naturally occurring copper-binding tripeptide found in human plasma, saliva and urine. Early human data
- Selective ghrelin-receptor agonist Ipamorelin Ipamorelin is a five-residue ghrelin-receptor agonist described in 1998 as the first selective growth hormone secretagogue. Human RCTs
- Mitochondrial-derived peptide MOTS-c MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA, discovered in 2015. Animal studies
Reconstitution calculator
Milligrams, millilitres and syringe units
Lyophilized peptides arrive as a dry powder measured in milligrams. Once you add water, the question becomes how many units on a U-100 insulin syringe hold a given amount. The calculator does that conversion, works backwards to the water volume, handles multi-compound blends and estimates cost per month.
It never suggests an amount. You bring the numbers; it does the arithmetic and flags draws that are too small to measure accurately or too large for the syringe.
Browse by research area
- Metabolic and GLP-1Incretin, amylin and glucagon receptor agonists studied for obesity, type 2 diabetes and liver fat.17 compounds
- Tissue repair and recoveryPeptides studied in tendon, ligament, gut and wound-healing models.10 compounds
- Growth hormone axisGHRH analogs and ghrelin-receptor agonists that raise the body’s own growth hormone release.10 compounds
- Cognitive and neurologicalNeuropeptides and analogs studied for anxiety, stroke recovery, sleep and memory.10 compounds
- Mitochondrial and longevityMitochondrial-derived peptides, cardiolipin-targeting compounds, NAD+ and senolytic candidates.10 compounds
Learn
Guides written to be checked, not trusted
- Research reviewSemaglutide vs tirzepatide vs retatrutide: what the trials showA side-by-side look at weight-loss results from the STEP, SURMOUNT and TRIUMPH trials, how the drugs differ in mechanism, and why cross-trial comparisons need care.
- Lab practicePeptide reconstitution: a bench guideHow lyophilized peptides are reconstituted in a lab: choosing a diluent, aseptic technique, mixing without damage, and storage before and after adding water.
- QualityHow to read a peptide certificate of analysisWhat HPLC purity, mass spectrometry identity, net peptide content, endotoxin and counter-ion results on a peptide COA mean, and the red flags to look for.
- MethodHow to evaluate peptide researchA practical guide to judging peptide studies: the evidence hierarchy, why rodent results often fail in people, single-lab literatures, surrogate endpoints and company press releases.
- RegulationThe regulatory status of research peptides in the US (2026)What “research use only” means, the difference between approved, compounded and research peptides, FDA compounding categories, and the 2026 changes affecting BPC-157 and others.
- Research reviewRetatrutide clinical trial results, phase 2 to phase 3Results from retatrutide’s phase 2 obesity and diabetes trials and the 2026 TRIUMPH phase 3 topline data: weight loss by dose, liver fat, heart rate and side effects.
Method
How each profile is built
Primary sources first
Claims trace to peer-reviewed papers, trial registries, regulator documents or, where noted, company announcements awaiting publication.
Evidence before mechanism
We state who was studied and how before explaining why a compound might work. Mechanism without outcome data is labelled as such.
Dated and revised
Each page shows when it was last reviewed. Regulatory status changes often; we update it when regulators act, not when rumours spread.
Frequently asked questions
What is Peptide Federation?
An independent reference that summarizes published research on 85 peptides and related compounds. Every profile states the compound’s regulatory status, the strength of its evidence and the studies behind each claim.
Do you sell peptides?
No. We do not sell, manufacture or distribute any compound, and we do not accept payment for placement or reviews.
Is the calculator a dosing tool?
No. It converts between milligrams, millilitres and syringe units for numbers you supply. It does not suggest amounts and cannot check purity or accuracy.
How do you rate evidence?
Each compound carries one of five labels, from “Approved medicine” to “Cell studies”, based on the strongest type of evidence available. See our editorial policy for the criteria.
Are research peptides legal?
It depends on the compound, the country and the purpose. Many are sold in the US labelled “for research use only”, which does not make them approved or safe for people. See our guide to regulatory status.