Category
Sexual and reproductive health
This group includes approved medicines (bremelanotide, gonadorelin, triptorelin, hCG, oxytocin) alongside research compounds such as kisspeptin-10. The approved products are prescription drugs with defined indications and monitoring requirements.
7 compounds, strongest evidence first
- Gonadotropin-releasing hormone Gonadorelin Gonadorelin is synthetic GnRH, identical to the natural hypothalamic hormone. Approved medicine
- Glycoprotein hormone hCG Human chorionic gonadotropin is the hormone that pregnancy tests detect. Approved medicine
- Neurohypophyseal hormone Oxytocin Oxytocin is a nine-amino-acid hormone made in the hypothalamus. Approved medicine
- Melanocortin receptor agonist PT-141 PT-141 (bremelanotide) is a cyclic melanocortin agonist approved by the FDA in 2019 as Vyleesi, an on-demand injection for low sexual desire in premenopausal women. Approved medicine
- GnRH agonist Triptorelin Triptorelin is a long-acting GnRH agonist. Approved medicine
- Reproductive neuropeptide Kisspeptin-10 Kisspeptin is the master upstream signal of the reproductive axis: it triggers the hypothalamus to release GnRH, which in turn drives LH and FSH. Human RCTs
- Non-selective melanocortin agonist Melanotan II Melanotan II is a synthetic cyclic peptide developed at the University of Arizona in the 1990s as a sunless tanning agent. Early human data